Detection and Mitigation of Cyber Attacks on Time Synchronization Protocols for the Smart Grid

The current electric grid is considered as one of the greatest engineering achievements of the twentieth century. It has been successful in delivering power to consumers for decades. Nevertheless, the electric grid has recently experienced several blackouts that raised several concerns related to its availability and reliability. The aspiration to provide reliable and efficient energy, and contribute to environment protection through the increasing utilization of renewable energies are driving the need to deploy the grid of the future, the smart grid. It is expected that this grid will be self-healing from power disturbance events, operating resiliently against physical and cyber attack, operating efficiently, and enabling new products and services. All these call for a grid with more Information and Communication Technologies (ICT). As such, power grids are increasingly absorbing ICT technologies to provide efficient, secure and reliable two-way communication to better manage, operate, maintain and control electric grid components. On the other hand, the successful deployment of the smart grid is predicated on the ability to secure its operations. Such a requirement is of paramount importance especially in the presence of recent cyber security incidents. Furthermore, those incidents are subject to an augment with the increasing integration of ICT technologies and the vulnerabilities they introduce to the grid. The exploitation of these vulnerabilities might lead to attacks that can, for instance, mask the system observability and initiate cascading failures resulting in undesirable and severe consequences. In this thesis, we explore the security aspects of a key enabling technology in the smart grid, accurate time synchronization. Time synchronization is an immense requirement across the domains of the grid, from generation to transmission, distribution, and consumer premises. We focus on the substation, a basic block of the smart grid system, along with its recommended time synchronization mechanism - the Precision Time Protocol (PTP) - in order to address threats associated with PTP, and propose practical and efficient detection, prevention, mitigation techniques and methodologies that will harden and enhance the security and usability of PTP in a substation. In this respect, we start this thesis with a security assessment of PTP that identifies PTP security concerns, and then address those concerns in the subsequent chapters. We tackle the following main threats associated with PTP: 1) PTP vulnerability to fake timestamp injection through a compromised component 2) PTP vulnerability to the delay attack and 3) The lack of a mechanism that secures the PTP network. Next, and as a direct consequence of the importance of time synchronization in the smart grid, we consider the wide area system to demonstrate the vulnerability of relative data alignment in Phasor Data Concentrators to time synchronization attacks. These problems will be extensively studied throughout this thesis, followed by discussions that highlight open research directions worth further investigations

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. For example, a key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process versus those that measure fl ux through the autophagy pathway (i.e., the complete process including the amount and rate of cargo sequestered and degraded). In particular, a block in macroautophagy that results in autophagosome accumulation must be differentiated from stimuli that increase autophagic activity, defi ned as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (inmost higher eukaryotes and some protists such as Dictyostelium ) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the fi eld understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. It is worth emphasizing here that lysosomal digestion is a stage of autophagy and evaluating its competence is a crucial part of the evaluation of autophagic flux, or complete autophagy. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. Along these lines, because of the potential for pleiotropic effects due to blocking autophagy through genetic manipulation it is imperative to delete or knock down more than one autophagy-related gene. In addition, some individual Atg proteins, or groups of proteins, are involved in other cellular pathways so not all Atg proteins can be used as a specific marker for an autophagic process. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field

Dr. Robert H. Goddard.

There are four main objectives regarding Dr. Robert H. Goddard in the IQP. The first objective is to develop an understanding of how important Dr. Robert H. Goddard\u27s contribution to the field of rocketry was. The second objective is to determine the impact that Goddard has had on the Worcester community and the community of Roswell, NM. The next objective is to analyze the books written about Goddard. These will also be compared to the number of books written about other popular figures in the aerospace field. The fourth and final objective will be to determine literacy of Goddard\u27s scientific work among Worcester college students